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Non-Healing-Wounds include:

  • Diabetic Foot Ulcers

  • Pressure Ulcers

  • Non-Healing Surgical Wounds

  • Arterial Insufficiency Ulcers

  • Venous Leg Ulcers

  • Burns

  • Many Combat Wounds

Non-Healing wounds fail to heal in the normal timeline of 30 days because they get stuck in a chronic inflammatory state
(Phase 2 in Figure below)

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Most, if not all non-healing wounds stall in the inflammatory phase of wound healing due to Microbial Biofilm Infection.

Biofilm is very difficult to treat and is not killed by normal antibiotic therapy.

1, 2

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It is also very difficult for wound physicians to determine whether the wound treatment strategy for individual non-healing wounds is killing the biofilm infection.

 

This is because there is currently no point-of-care diagnostic that provides a quantitative measurement of biofilm infection.


Wound care physicians must determine whether wounds are healing or not by a very slow method of sensory perception including:
 

  • What the wound looks like

  • What the wound smells like

  • Whether a wound is sore to the touch

  • Listening to the patient history of the wound

  • A sixth sense born of experience

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PeloGenix is developing a quantitative, point-of-care diagnostic of wound infection to indicate whether a wound is on a healing trajectory from one patient visit with their doctor to the next.


1 Schultz G, et al. Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds. Wound Rep Reg 2017, 25:744-757.


2 Hurlow J. Clinical investigation of biofilm in non-healing wounds by high resolution microscopy techniques. J Wound Care 2016, 25(Suppl 9): S11-S22.