Non-Healing-Wounds include:
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Diabetic Foot Ulcers
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Pressure Ulcers
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Non-Healing Surgical Wounds
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Arterial Insufficiency Ulcers
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Venous Leg Ulcers
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Burns
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Many Combat Wounds
Non-Healing wounds fail to heal in the normal timeline of 30 days because they get stuck in a chronic inflammatory state
(Phase 2 in Figure below)
Most, if not all non-healing wounds stall in the inflammatory phase of wound healing due to Microbial Biofilm Infection.
Biofilm is very difficult to treat and is not killed by normal antibiotic therapy.
1, 2
It is also very difficult for wound physicians to determine whether the wound treatment strategy for individual non-healing wounds is killing the biofilm infection.
This is because there is currently no point-of-care diagnostic that provides a quantitative measurement of biofilm infection.
Wound care physicians must determine whether wounds are healing or not by a very slow method of sensory perception including:
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What the wound looks like
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What the wound smells like
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Whether a wound is sore to the touch
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Listening to the patient history of the wound
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A sixth sense born of experience
PeloGenix is developing a quantitative, point-of-care diagnostic of wound infection to indicate whether a wound is on a healing trajectory from one patient visit with their doctor to the next.
1 Schultz G, et al. Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds. Wound Rep Reg 2017, 25:744-757.
2 Hurlow J. Clinical investigation of biofilm in non-healing wounds by high resolution microscopy techniques. J Wound Care 2016, 25(Suppl 9): S11-S22.